Severe acute respiratory syndrome coronavirus 2 is the virus responsible for coronavirus disease 2019 (COVID-19), which caused a global pandemic and then became an endemic condition. COVID-19 infection may be associated with clinical manifestations such as respiratory symptoms and systemic diseases, including neurological disorders, notably headaches. Headaches are a common neurological symptom in individuals infected with COVID-19. Furthermore, with the transition to endemicity, COVID-19 infection-related headaches may reportedly persist in the acute phase of COVID-19 infection and in the long term after COVID-19 infection resolves. Persistent headaches after COVID-19 infection can be a significant concern for patients, potentially leading to disability. The present review discusses the clinical characteristics and potential underlying mechanisms of COVID-19 infection-related headaches.
Citations
Citations to this article as recorded by
Unclosing Clinical Criteria and the Role of Cytokines in the Pathogenesis of Persistent Post-COVID-19 Headaches: A Pilot Case-Control Study from Egypt Ahmed Abualhasan, Shereen Fathi, Hala Gabr, Abeer Mahmoud, Diana Khedr Clinical and Translational Neuroscience.2025; 9(1): 5. CrossRef
Exploring Secondary Headaches: Insights from Glaucoma and COVID-19 Infection Soo-Kyoung Kim Headache and Pain Research.2025; 26(1): 3. CrossRef
Calcitonin Gene-Related Peptide Monoclonal Antibody Treatment in Nine Cases of Persistent Headache Following COVID-19-Infection Soyoun Choi, Yooha Hong, Mi-Kyoung Kang, Tae-Jin Song, Soo-Jin Cho Journal of Korean Medical Science.2025;[Epub] CrossRef
A Prospective Multicenter Study on the Evaluation of Frequency of Idiopathic Intracranial Hypertension in Korea Byung-Su Kim, Soo-Jin Cho, Kyung-Hee Cho, Seol-Hee Baek, Jong-Hee Sohn, Tae-Jin Song, Wonwoo Lee, Hong-Kyun Park, Soohyun Cho, Junhee Han, Soolienah Rhiu, Myoung-Jin Cha, Mi Ji Lee, Min Kyung Chu Journal of Korean Medical Science.2025;[Epub] CrossRef
Global, regional, and national burden of headache disorders, 1990–2021, with forecasts to 2050: A Global Burden of Disease study 2021 Tissa Wijeratne, Jiyeon Oh, Soeun Kim, Yesol Yim, Min Seo Kim, Jae Il Shin, Yun-Seo Oh, Raon Jung, Yun Seo Kim, Lee Smith, Hasan Aalruz, Rami Abd-Rabu, Deldar Morad Abdulah, Richard Gyan Aboagye, Meysam Abolmaali, Dariush Abtahi, Ahmed Abualhasan, Rufus A Cell Reports Medicine.2025; : 102348. CrossRef