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Review Article
- Understanding the Connection between the Glymphatic System and Migraine: A Systematic Review
- Myoung-Jin Cha, Kyung Wook Kang, Jung-won Shin, Hosung Kim, Jiyoung Kim
- Headache Pain Res. 2024;25(2):86-95. Published online July 31, 2024
- DOI: https://doi.org/10.62087/hpr.2024.0014
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- 137 Download
- 2 Citations
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Abstract
PDF - The glymphatic system is a brain-wide perivascular pathway that functions similarly to the lymphatic system in the periphery of the body, playing a crucial role in removing waste from the brain. Although impaired glymphatic function has a well-known relationship with neurodegenerative diseases through abnormal protein accumulation, it is also associated with migraine. While still in its nascent phase, research on the glymphatic system in migraine patients is gradually increasing. This systematic literature review focuses on studies investigating the glymphatic system in migraineurs. Furthermore, it examines the methods used to evaluate the glymphatic system in these studies and their main findings.
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Citations
Citations to this article as recorded by
- Chronic Migraine Is Associated With Region-Specific High-Grade Enlarged Perivascular Spaces: Retrospective Matched Case-Control Study
Jae Wook Cho, Gha-Hyun Lee, Jiyoung Kim
Journal of Clinical Neurology.2026; 22(1): 113. CrossRef - Diffusion Tensor Imaging-Based Glymphatic Dysfunction Assessments in Migraine Syndromes: Mechanisms and Diagnostic Implications
Emily Lai, Joshua Estin, Jiahao Zhou, Roger Sheffmaker, Manisha Koneru
Biomedicines.2025; 13(12): 2981. CrossRef
- Chronic Migraine Is Associated With Region-Specific High-Grade Enlarged Perivascular Spaces: Retrospective Matched Case-Control Study
- 무거운 가방을 메고 싸이클링은 한 후 발생한 자발성 기립성 저혈압의 예
- Jung-Won Shin, Hyung-Min Kwon
- Korean J Headache. 2012;13(1):41-42. Published online June 30, 2012
- 851 View
- 98 Download
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Abstract
PDF
- Spontaneous intracranial hypotension (SIH) is important cause of daily persistent headache and trivial traumatic events precede the onset of symptoms in about one third of patients. One patient presented with spinal cerebral fluid leakage manifesting as disabling headache after cycling with backpack. We discuss that wearing heavy backpack for a long time can affect musculoskeletal and soft tissue injury in the spine, then this event can result in SIH.
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